Total Synthesis of Natural Products: Case Studies in the Evaluation of New Synthetic Methods, Structural Elucidation and Drug Discovery

Authors

  • Lukáš Rýček Department of Organic chemistry, Faculty of Science, Charles University, Prague, Czech Republic http://orcid.org/0000-0003-3028-8829

DOI:

https://doi.org/10.54779/chl20220204

Keywords:

natural products and derivatives, total synthesis, biological activity

Abstract

This review summarizes our work in the field of synthesis of natural products and their derivatives. Application of modern synthetic method is discussed in the context of the syntheses of both enantiomers of hydromorphone, (–)-tetrodotoxin (a marine toxin), and selaginpulvilins C and D (natural fluorene derivatives). Further, synthesis of notoincisol A, selagibenzophenones A and B is described to clarify the structural aspects of the compounds. Last but not least, synthesis and pharmaceutical profilation of derivatives of magnolol and honokiol is discussed as well.

Fulltext of this article is available on the website of this Journal.

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Published

2022-04-15

How to Cite

Rýček, L. (2022). Total Synthesis of Natural Products: Case Studies in the Evaluation of New Synthetic Methods, Structural Elucidation and Drug Discovery. Chemické Listy, 116(4), 204–214. https://doi.org/10.54779/chl20220204

Issue

Vol. 116 No. 4 (2022)

Section

Articles