Anticancer and Anti-HIV Derivatives of Betulinic Acid

Authors

  • D. Kodr Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague
  • M. Rumlová Department of Biotechnology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague
  • T. Zimmermann Departmen of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague
  • P. Džubák Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc
  • P. Drašar Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague
  • M. Jurášek Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague

Keywords:

betulinic acid, anti-HIV-1, anti-HIV-2, antitumor activity

Abstract

Betulinic acid and its derivatives modifying its physicochemical and biological properties contain a promising pharmacophore, which, so far only experimentally, are used as a structural basis for substances that function as antitumor and anti-HIV-1 and -2 agents. An overview of derivatives, classified according both structural characteristics and the type of the effect, is given. Although betulinic acid has been extensively studied since the 1990s, it has not yet been possible to prepare any sufficiently effective and safe derivative useful in clinical practice that could be marketed as a registered drug.

Full text English translation available in the on-line version.

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Published

2020-10-15

How to Cite

Kodr, D., Rumlová, M., Zimmermann, T., Džubák, P., Drašar, P., & Jurášek, M. (2020). Anticancer and Anti-HIV Derivatives of Betulinic Acid. Chemické Listy, 114(10), 658–667. Retrieved from http://w-ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3709

Issue

Vol. 114 No. 10 (2020)

Section

Articles