Sesquiterpene Lactones: From Weed to Remedy

Authors

  • L. Peterková Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague
  • S. Rimpelová Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague | Institute of Pharmacology and Toxikology, Faculty of Medicine in Pilsen, Charles University, Pilsen
  • E. Kmoníčková Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague | Institute of Experimental Medicine, The Czech Academy of Sciences, Prague | Institute of Pharmacology and Toxikology, Faculty of Medicine in Pilsen, Charles University, Pilsen
  • T. Ruml Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague

Keywords:

natural compounds, sesquiterpene lactones, sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA), thapsigargin, trilobolide, parthenolide, cynaropicrin, anticancer activity

Abstract

Sesquiterpene lactones are bioactive natural compounds with anticancer, antiprotozoal, immunomodulatory, antibacterial and antiviral activity which have potential for drug development. The aim of this review article is to provide a brief insight into the field of sesquiterpene lactones: the main mechanisms of their biological actions, as well as particular compounds, are described, some of which have already become a basis of a drug development and are being tested in clinical trials.

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Published

2019-03-15

How to Cite

Peterková, L., Rimpelová, S., Kmoníčková, E., & Ruml, T. (2019). Sesquiterpene Lactones: From Weed to Remedy. Chemické Listy, 113(3), 149–155. Retrieved from http://w-ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3314

Issue

Vol. 113 No. 3 (2019)

Section

Articles