Electrochemical Determination of Toxic Indoxyl Sulfate in Biological Matrix

Authors

  • L. Portychová Research Institute of Organic Synthesis, Rybitví ǀ Faculty of Science, Palacky University, Olomouc
  • K. Štochlová Research Institute of Organic Synthesis, Rybitví
  • R. Hyšpler Department of Research and Development of University Hospital Hradec Kralove, Hradec Králové
  • Z. Nývltová Research Institute of Organic Synthesis, Rybitví

Keywords:

indoxyl sulfate, HPLC, electrochemical detection, uremic toxin, urine, blood serum

Abstract

The study is focused on optimization and validation of methods for determination of toxic indoxyl sulfate in human urine and blood serum. Samples were analyzed using HPLC/ED-DAD system after the biological matrix had been pretreated. Validated methods were successfully tested on samples from healthy people as well as from dialyzed patients. The aim was to monitor both indoxyl sulfate levels and impact of various methods for elimination of this toxin from patients with renal disease.

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Published

2020-10-15

How to Cite

Portychová, L., Štochlová, K., Hyšpler, R., & Nývltová, Z. (2020). Electrochemical Determination of Toxic Indoxyl Sulfate in Biological Matrix. Chemické Listy, 114(10), 674–679. Retrieved from http://w-ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3711

Issue

Vol. 114 No. 10 (2020)

Section

Articles