Using the Ellman Method for In Vivo Testing of Cholinesterase Activity

Authors

  • J. Žďárová-Karasová Department of Toxicology, Faculty of Military Health Service, Defence University, Brno
  • K. Kuča Department of Toxicology, Faculty of Military Health Service, Defence University, Brno
  • D. Jun Department of Toxicology, Faculty of Military Health Service, Defence University, Brno
  • J. Bajgar Department of Toxicology, Faculty of Military Health Service, Defence University, Brno

Abstract

The changes in cholinesterase activity in tissues were evaluated and compared with the reactivation potential of reactivators. As reactivators, (E)-1-(4-carbamoylpyridi¬nium-1-yl)-4-{4-[(hydroxyimino)methyl]pyridinium-1-yl}but-2-ene dibromide (K203) and common 1,3-bis{4-[(hydroxyimino)methyl]pyridinium-1-yl}-2-oxapropane dichloride (obidoxime) were used. The reactivation of both oximes was monitored in blood and blood plasma. The reactivation of tabun-inhibited acetylcholinesterase (AChE) was higher using the newly synthesized K203.

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Published

2010-02-15

How to Cite

Žďárová-Karasová, J., Kuča, K., Jun, D., & Bajgar, J. (2010). Using the Ellman Method for In Vivo Testing of Cholinesterase Activity. Chemické Listy, 104(1). Retrieved from http://w-ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1419

Issue

Vol. 104 No. 1 (2010)

Section

Articles

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