Determination of the Thickness of Tablet Coating by Near-Infrared Spectroscopy

Authors

  • J. Muselík Department of Pharmaceutics,
  • K. Krejčová Department of Pharmaceutics,
  • M. Rabišková Department of Pharmaceutics,
  • A. Bartošíková Department of Pharmaceutics,
  • M. Dračková Institute of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
  • L. Vorlová Institute of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Abstract

The aim of this study was to develop a fast and reliable method for determination of tablet coating thickness. Tablets were coated with polymeric Pharmacoat® 606 in a laboratory coater. The coating thickness was measured by near-IR absorption of the coating material using calibration. The calibration and validation results afforded the following parameters: determination coefficient R2 > 0.97, the number of factors 6 and the standard error of cross-validation 5.4 μm at the coating thickness 25125 μm. The obtained results confirmed suitability of the method for evaluation of coating quality.

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Published

2010-02-15

How to Cite

Muselík, J., Krejčová, K., Rabišková, M., Bartošíková, A., Dračková, M., & Vorlová, L. (2010). Determination of the Thickness of Tablet Coating by Near-Infrared Spectroscopy. Chemické Listy, 104(1). Retrieved from http://w-ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1418

Issue

Vol. 104 No. 1 (2010)

Section

Articles