Using the Ellman Method for In Vivo Testing of Cholinesterase Activity

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  • J. Žďárová-Karasová Department of Toxicology, Faculty of Military Health Service, Defence University, Brno
  • K. Kuča Department of Toxicology, Faculty of Military Health Service, Defence University, Brno
  • D. Jun Department of Toxicology, Faculty of Military Health Service, Defence University, Brno
  • J. Bajgar Department of Toxicology, Faculty of Military Health Service, Defence University, Brno

Abstrakt

The changes in cholinesterase activity in tissues were evaluated and compared with the reactivation potential of reactivators. As reactivators, (E)-1-(4-carbamoylpyridi¬nium-1-yl)-4-{4-[(hydroxyimino)methyl]pyridinium-1-yl}but-2-ene dibromide (K203) and common 1,3-bis{4-[(hydroxyimino)methyl]pyridinium-1-yl}-2-oxapropane dichloride (obidoxime) were used. The reactivation of both oximes was monitored in blood and blood plasma. The reactivation of tabun-inhibited acetylcholinesterase (AChE) was higher using the newly synthesized K203.

Stahování

Publikováno

15.02.2010

Jak citovat

Žďárová-Karasová, J., Kuča, K., Jun, D., & Bajgar, J. (2010). Using the Ellman Method for In Vivo Testing of Cholinesterase Activity. Chemické Listy, 104(1). Získáno z http://w-ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1419

Číslo

Vol 104 No 1 (2010)

Sekce

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